What is the MRT Food Sensitivity Test?

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Discover how the MRT Food Sensitivity Test combined with the LEAP Dietary Protocol can quickly and significantly improve the quality of life for those living with autoimmune and inflammatory conditions.

What is LEAP & the MRT Food Sensitivity Test by Emily Kyle Nutrition

Relief For Autoimmune & Inflammatory Conditions

Are you suffering from a stubborn health problem that won’t go away, no matter what you try? Or perhaps medications and treatments you’re taking are not actually getting to the root cause of your illness – but you want something that will? 

Millions of Americans suffer from food sensitivities.

Many common health problems are often directly related to specific immune reactions to the foods we eat. Even so-called ‘healthy’ food such as salmon, broccoli, or garlic can provoke symptoms in sensitive individuals. 

The first thing a food sensitivity suffer needs to do is identify their trigger foods and food-chemicals. This is easier said than done because food sensitivity reactions may be delayed by hours, or even days after ingestion. Oftentimes, food sensitivities can also be dose-related, making proper identification difficult, if not impossible.

Fortunately, the gold standard in food sensitivity testing, the Mediator Release Test (MRT) blood test that accounts for Type 3 and 4 hyper-sensitivity pathway reactions, can help you quickly overcome even the most troublesome food sensitivity related problems. This test identifies reactions to 170 different food and food-chemicals. 

Combined with the Lifestyle Eating and Performance Therapy (LEAP) protocol, the program can provide support beyond the testing alone by providing counseling that provides you with the opportunity to get the maximum benefit from your test results. 

LEAP has helped thousands of patients across the country turn years of suffering into a bright, happy, healthy future, free of the symptoms that once seems an inescapable part of life.

If you want the best, you can have it with LEAP.

What Are Food Sensitivities?

Food sensitivities are a very complex immune system reaction that can cause individuals to feel sick and to display a variety of adverse symptoms such as digestive issues, headaches, joint and muscle pain, fatigue, weight imbalances, and more.

In the case of food sensitivities, the immune system reacts to various food substances that cause the release of chemicals called mediators (such as histamine, prostaglandins, cytokines) from the white blood cells in the body.

These mediators cause inflammation, pain, and other symptoms that are negatively associated with food sensitivities. There are many different cells that have different profiles of mediators, many mechanisms that cause mediators to be released, and many different mediators themselves.

What is the Difference Between an Allergy, a Sensitivity, and an Intolerance?

Food allergies, food sensitivities, and food intolerances are often used interchangeably, and incorrectly. In fact, there is an active debate in scientific and medical circles as to how to define and use these three terms.

The general consensus is that a food allergy can be defined as any adverse reaction to food that involves our immune system.

This further breaks down into two kinds of reactions, food allergy, and food sensitivity. Food intolerance does not involve the immune system, such in the case of lactose intolerance which involves the digestive system.

What is a Food Allergy?

The best-known example of food allergy is also its least common, and most dangerous. Anaphylactic shock is a severe hyper-reaction of the immune system caused by a massive release of histamine and other chemical mediators from certain types of white blood cells called mast cells and basophils. Not everyone with food allergies experiences anaphylaxis.

Food allergies affect about 1-2% of the population and account for only a small percentage of all adverse food reactions. People suffering from a food allergy can often identify what foods they are allergic to without the help of a doctor or diagnostic testing.

What is a Food Sensitivity?

A food sensitivity, also known as a delayed food allergy, is different from a true food allergy. Delayed reactions manifest in many different ways, and they can affect any organ system in the body. It can take anywhere from 45-minutes to several days for symptoms to become apparent.

The delayed onset of symptoms and complex physiological mechanisms involved in food sensitivities make them an especially difficult puzzle to try to solve, either on your own or with most laboratory serum tests.

It is a fact that food sensitivities often go undiagnosed or misdiagnosed. The treatments prescribed usually provide only temporary relief that masks the symptoms instead of addressing the root cause of the problem.

Researchers do not have all the answers to food sensitivities, and there is still much to be learned about how food sensitivities develop. The following are the most widely accepted factors that cause food sensitivities:

  • Poor digestion
  • Unbalanced gut flora
  • Chronic stress or severe trauma
  • Immune system overload
  • Genetics
  • Toxic-induced loss of oral tolerance (overexposure to chemicals)

What is a Food Intolerance?

Food intolerances can produce some digestive symptoms that are similar to food sensitivities, but the reaction doesn’t involve the immune system. Instead, when the food in question is consumed, it is not properly digested and begins to ferment inside the gut.

The best example of food intolerance is lactose intolerance. This condition is characterized by bloating, loose stools or diarrhea, and gas. Lactose intolerance is caused by an inability of the body to produce enough of the enzyme lactase, which breaks down lactose, the primary sugar found in milk.

Avoiding milk products or supplementing the diet with the lactase enzyme is the best way for a person with lactose intolerance to overcome the problem.

What is the MRT Food Sensitivity Test?

Food sensitivity reactions affect 20-30% of the US population. The Mediator Release Test (MRT) is the most accurate test available to identify foods, additives, and chemicals that are causing food sensitivity reactions.

MRT is a patented blood test that quantifies how strongly your immune cells react to the food and food chemicals tested by measuring intracellular mediator release indirectly.

When released from immune cells, chemical mediators such as histamine, cytokines, and prostaglandins produce damaging effects on body tissues, leading to the development of food symptoms.

Identifying which foods and food chemicals are causing one’s problems is the first step towards improving the health of those suffering from food sensitivities.

How Does the MRT Test Work?

Mediator Release Test is an indirect method of accurately measuring mediator release. MRT does this by measuring changes in the liquids to solids ratio of your blood after your blood as been exposed and incubated with the test substance.

It accounts for all reactions by your immune cells. This is done as an indicator that your immune cells have released chemical mediators such as histamines and others. Significant reactions are broken into either reactive or moderately reactive categories and insignificant reactions in the low-reactive category.

All measurements are made using the most accurate method of measurement, ribbon technology, currently available by Oxford Biomedical Technologies, Inc.

The Mediator Release Test is a safe blood test that is done in a practitioner’s office with a certified phlebotomist. The results show up in less than a week in an easy-to-read, color-coded bar chart.

The results are then implemented with the help of your LEAP practitioner by following the LEAP dietary protocol for eliminating and reintroducing foods.

Who Does the MRT Food Sensitivity Test Help?

Millions of Americans suffer from food sensitivities and related chronic health conditions every day, without relief.

If foods and food additives in the diet are causing the illness, whatever medications are taken will ultimately fail because they only mask the symptoms because they don’t treat the underlying cause of the symptoms.

If food sensitivities are causing your illness and you don’t properly address them, you could easily end up suffering for many years, possibly spending thousands of dollars for treatments that will never work.

Over the years, the MRT Food Sensitivity Test has helped to provide answers and true healing to those suffering from the following conditions:

  • Irritable Bowel Syndrome (IBS) and Irritable Bowel Disease (IBD)
  • Migraines & Other Headaches
  • Fibromyalgia
  • Arthritis, Joint Pain & Muscle Pain
  • Autism, ADD & ADHD
  • Urticaria
  • Chronic Fatigue Syndrome
  • Obesity or Weight Imbalances
  • Mystery symptoms such as acid reflux, skin eruptions, brain fog and more.

How is the MRT Food Sensitivity Test Different from IgG, Elisa IgG, or ALCAT Testing?

The thing that makes food sensitivities complicated is the various ways that the immune system can respond in hypersensitivity. Because there are different ways the immune system can respond, there are different approaches researchers have tried to identify reactive food and food chemicals.

MRT Compared to IgG Testing

There are a number of advantages of MRT over any form of IgG testing.

MRT is an endpoint test, meaning that all the immune-based adverse reactions end up causing mediator release. MRT does this without caring about the mechanism. In fact, MRT is able to take into account all the actions of all mechanisms, whether they are antibodies or other because all of them ultimately cause white blood cells to release mediators.

MRT is able to account for a much wider array of reactions than the relatively simple IgG testing. MRT is also able to identify reactions to chemicals. Overall, MRT is more accurate and useful clinically.

ELISA IgG Testing

This test quantifies how much IgG you are producing to a specific food, with the assumption that high levels of IgG are only a bad thing. There is a specific type of immune reaction called Type 3 Hypersensitivity that can involve IgG or another antibody called IgM. When IgG is involved in triggering mediator release, this testing will be very helpful.

Unfortunately, there are three very serious limitations of IgG testing:

  1. High levels of IgG can be either good (suppressing of an immune response) or bad (causing an immune response). But you cannot tell which is good IgG or which is bad IgG through this testing. Just because you have a high level, it may actually be good, not bad.
  2. IgG only plays a minor role in conditions like IBS, migraine, and fibromyalgia. Instead, research shows that Type 4 Hypersensitivity is the primary type of reaction. Type 4 Hypersensitivity doesn’t involve IgG or any other antibodies.
  3. IgG testing cannot identify reactions to chemicals like food additives. It is clearly documented that food chemicals play a very important role in provoking symptoms in many conditions. If you cannot identify these reactions, you could very well be missing very important information that can impact your health.

MRT Compared to ALCAT Testing

The ALCAT Test was invented and patented by the same physician who invented and patented the MRT test, Dr. Mark Pasula. The two technologies are similar, yet separately patented, which means there is a unique difference.

The main difference between the two tests is in terms of accuracy and reliability. Side by side studies has shown the MRT test to be more accurate, with higher sensitivity and specificity, and to have higher split sample reproducibility than ALCAT. It is good, but an older method that has been replaced by MRT testing.

LRA by ELISA-Act Compared to MRT

This test is somewhat of a mystery as to what it actually measures and how that correlates with mediator release and with involvement in IBS, migraine, fibromyalgia, or other food sensitivity-related conditions.

The company that invented it makes claims about its accuracy, reproducibility, and validity, but in fact, there are no actual third-party studies that confirm any of their claims. Nor have their own studies related to the same been published.

In addition, the actual methodology is not described or validated in any peer-review publications, yet they claim that it is. Therefore it is not possible to assess and compare its strengths and weaknesses to MRT.

The main difference between MRT and ELISA-Act is that of scientific validation. There are studies published on MRT that clearly show the methodology, accuracy, ability to discriminate between health and sick populations, etc. They clearly tie the relationship to what MRT is measuring to the physiological basis of adverse food reactions in IBS, migraine, fibromyalgia, and other food sensitivity-related conditions.

How Accurate is MRT Testing?

A blinded, peer-review scientific study showed MRT to have the highest level of accuracy of any food sensitivity blood test (94.5% sensitivity and 91.8% specificity).

MRT Compared to Other Food Sensitivity Tests

There are dozens of food sensitivity tests out there on the market today, all claiming to be the ‘best’. Unfortunately, many of these tests are not reliable, accurate, or evidence-based, leading to patients wasting hundreds of thousands of dollars every year.

For a comprehensive review of the MRT, test compared to other food sensitivity tests out there on the market today, review the evidence-based research presented by Functional Nutrition Answers on What is the Best Food Sensitivity Test.

Why the LEAP Protocol and MRT Testing?

I never knew what type of dietitian I wanted to be until I experienced my own health crisis in the Spring of 2017.

After being bedridden for nearly two months, with little to no answers from my doctor, I was ultimately given a vague diagnosis, an unhealthy amount of prescription medications, and a ‘we don’t know how to help you, but consider seeing a functional medicine doctor‘ sympathy statement on my way out the door.

My condition was made worse by the current Western medicine approach of only treating the current symptoms and not the underlying cause of disease. I spent nearly two months in my bed, unable to care for myself or my son, plagued by fatigue, mystery pain, and a life-threatening infection that went untested, and untreated, for two weeks.

It wasn’t until I started to see an Integrative and Functional Medicine practitioner that I was able to heal myself with a food-based approach that included an elimination diet, a very specific supplement regimen, and a true adoption of a holistic lifestyle.

From that experience, I vowed that I would learn to practice functional nutrition in order to help others like myself who live with the terrible, debilitating symptoms of autoimmune disease and mystery inflammatory conditions.

Over the past two years, I have studied functional nutrition and the best way to treat conditions sparked by what is known as food sensitivities, such as autoimmune and inflammatory conditions.

I sought out the gold standard in food sensitivity testing to use in my practice and ultimately went back to school to become a Certified Lifestyle Eating and Performance Therapist trained to administer and interpret the results from the patent Mediator Release Test (MRT).

This comprehensive training was developed by a team of dietitians, physicians, immunologists, and medical business professionals with more than 100 years of combined experience in treating food sensitivity related conditions.

Lifestyle, Eating and Performance Therapy (LEAP) is the most strategic method of dealing with food sensitivity related illness that you can find anywhere in healthcare today.

This test and dietary protocol have been used to successfully treat thousands of patients with IBS, migraines, fibromyalgia, autism, ADD/ADHD, IBD, urticaria, chronic fatigue syndrome, obesity, and more, over the past decade.

What is LEAP & the MRT Food Sensitivity Test by Emily Kyle Nutrition
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