Have you heard that you need to pair edibles with fat for them to be effective? Fat can definitely affect how you make and react to edibles. Read on to learn how fat helps with infusions, absorption, and bioavailability to ensure you have the best experience possible.

Pairing Edibles With Fat: What's The Connection Graphic

Article Features

  • Why fat is the perfect medium for making potent infusions
  • Why eating edibles with dietary fat helps to increase bioavailability
  • Want to skip the hard work? Shop with me and have premium, high-quality cannabis products delivered directly to your door! Now shipping across the US.
A picture of Emily Kyles Bliss Products.

Why You Will Love This Guide

Recently, a member of my Well With Cannabis Community asked if it was true that you need to make or consume edibles with fats, and the answer is YES; there is plenty of truth to that!

When making homemade infusions, the THC, CBD, and other cannabinoids found in the cannabis plant are most soluble in fats like oil.

And when you consume a prepared edible, eating it with a fat source in your food can help to increase your body’s absorption of the cannabinoids.

These are two great reasons why we should pair cannabis with fat!

In this guide, we will explore these reasons in-depth so you can better understand how to get the most out of your edible experience.

#1 – Fat Makes Potent Infusions

There is a reason that cannabutter remains the most popular homemade edible recipe.

Or that other oils like coconut, olive, and MCT are the perfect medium for making potent infusions.

Cannabis researchers have discovered that cannabinoids are lipophilic, meaning they’re soluble in dietary fat.

When we make an oil infusion, the goal is to get the trichomes that contain the cannabinoids off of the plant material and into the oil or butter (without the unwanted extras, like chlorophyll).

The more fat in the oil, the more effective and, thus, more potent the infusion becomes.

This maximizes the efficacy of the euphoria-inducing THC and inflammation-reducing CBD.

This process is not to be confused with extraction methods that utilize solvents like high-proof alcohol to extract the trichomes from the plant material, resulting in a tincture.

#2 – Absorption and Bioavailability

When preparing your edibles with dietary fats like butter, vegetable oil, and whole milk, you may think the process is over, but it is really just beginning.

In the next step, consuming fat alongside your edible can help enhance the bioavailability and absorption of cannabinoids in the body.

When ingesting edibles, they pass through the digestive system and are eventually absorbed into the bloodstream.

Cannabinoids then interact with the endocannabinoid system (ECS).

However, not all the ingested cannabinoids enter the bloodstream, and that’s where the term “bioavailability” comes into play. 

Bioavailability means the amount of ingested THC and CBD that gets absorbed into the body and transmitted to the targeted tissues and organs.

It is the proportion of the active cannabinoids absorbed into the bloodstream compared to the dose.

For instance, if a 100 mg dose is consumed orally, and only 40 mg is absorbed in the body, then the drug’s bioavailability is 40%.

As reported in the American Journal of Translational Research, the THC and CBD bioavailability in the body increases by 2.5 and 3-fold when prepared using oils and fats, respectively.

That makes them more therapeutic and euphorically effective – a win for you!

Final Thoughts

As we explored above, two good reasons exist to pair fat with edibles.

The first is to create a potent infusion because cannabinoids are lipophilic, meaning they love fat.

The second is that consuming edibles paired with fat can increase the bioavailability and absorption in the body.

This can create a better, more potent experience.

You can learn how to make your own oil infusions here; it is really quite easy, and you can even make them in an Instant Pot.

Unable to have fat for a certain reason?

Have no fear! You can rely on cannabis tinctures to extract the cannabinoids for you. Learn more here.

About Emily

Hi, I’m Emily Kyle and I teach people just like you how to use cannabis to find joy, enhance productivity, improve relationships, and naturally support your overall health and wellness.

Leave a comment

Your email address will not be published. Required fields are marked *


  1. I’m so delighted with all this information. Good to know so we can always pair our FECO and other cannabis products with fat. Thank you, Emily!

  2. I love all your recipes! I’m new to infusing and love to try new recipes. You are a Great resource and your knowledge is invaluable. Thank you for doing all the research and trial and error for all of us !!!

  3. Wow, Bonnie, thank you so much for your kind words 😊 It truly warms my heart to know that you’re finding value in the recipes and information shared. As a fellow lover of infusing, it’s always a joy to experiment, learn, and share what I’ve discovered with wonderful readers like you. Thank you for being part of our community.

  4. Can you give examples of what fat (type, source) to pair with edibles?


  5. Of course, Brian. Here are some examples:

    – Saturated Fats – These are found in coconut oil, butter (especially from grass-fed cows), and palm oil. They are considered the best for binding with cannabinoids due to their saturated fat content.

    – Monounsaturated Fats – Olive oil and avocados are great sources. They are not as effective as saturated fats, but still a good choice for pairing with edibles.

    – Polyunsaturated Fats – These include nuts, seeds, and fish oil. While not the first choice for pairing with cannabinoids, they can still be beneficial due to their omega-3 and omega-6 fatty acids.

    Each type of fat has its unique benefits and can be used based on personal preferences and dietary restrictions.