Feeling like cannabis edibles just aren’t working for you? Or maybe you’re curious about how they actually work? Don’t worry—you’re not alone! There are a bunch of reasons why edibles don’t affect everyone the same way. I’ve got some simple tips and tricks to help you out and make your experience way better. Let’s figure it out together!
Table of Contents
Article Features
- Reasons why edibles may not work for everyone
- Tips and tricks to try and get edibles to work better
- Ready to experiment? Shop with me and have my high-quality cannabis edibles delivered directly to your doorstep. Now shipping across the US!
Why You Will Love This Guide
A lot of people absolutely love the way edibles make them feel—happy, relaxed, even euphoric.
They can also help with things like relieving pain or other discomforts, and THC edibles, in particular, can create a pretty intense high.
But here’s the thing—not everyone has that experience. If you’ve ever been left wondering, “Why don’t edibles get me high?” you’re definitely not alone!
Someone in my Well With Cannabis Community recently asked me this very same question.
And the truth is, there could be a few different reasons for it.
It’s going to take a little detective work to figure out what’s going on for you specifically.
This guide is here to walk you through some common reasons edibles might not be working for you and offer some tips to help you see if you can change how your body responds.
Why Edibles Don’t Work For Everyone
Before we get started, if you’re totally new to edibles, I recommend checking out my beginner’s guide to edibles first.
It’s a great way to get the basics down.
One thing to keep in mind is that your tolerance for smoking, vaping, or inhaling doesn’t affect your tolerance for edibles—they’re a whole different experience.
A lot of people choose edibles over smoking for good reasons. Health is a big one, but another reason is the experience itself.
The high you get from THC in edibles hits differently—it can feel stronger and affect your whole body.
Plus, the effects from edibles last longer, often four hours or more, which makes for a nice, sustained high.
They’re also super convenient and discreet, making them easy to enjoy when you’re out and about or around others.
That being said, not everyone gets the results they’re looking for with edibles.
Some people don’t feel anything at all, which can be frustrating. If that’s been your experience, don’t worry—you’re not alone.
There are a few possible reasons why this might happen, such as:
- You didn’t decarb
- You didn’t take a high enough dose
- Your body processes THC differently
- Your tolerance might be higher than expected
💡 We’ll break each of these down below so you can get a better idea of what’s going on!
You Didn’t Decarb First
If you’re new to making edibles, you might not realize that you need to decarb your cannabis first—it’s an important step!
Decarbing is what transforms the cannabinoid THCA into THC, which is the compound that gives you the effects you’re looking for.
The good news? It’s super easy to do. You can decarb your cannabis by simply baking it in your oven or even using an Instant Pot.
If you skip this step, though, your edibles probably won’t have the punch you’re expecting.
Whether you’re using flower buds, trim, kief, and many concentrates – decarbing is always a must before adding cannabis to your recipes!
You Didn’t Consume Enough
A friend of mine once said that she felt absolutely nothing after consuming edibles, even after trying several times.
As it turns out, she just needed a higher dose for it to kick in.
Just like how fast edibles kick in is different for everyone, the amount you need to feel the effect can also differ.
While some people get high with as little as 2mg of THC, others do so at 30mg, while others won’t feel the effect until the dosing is past 100mg or more.
All that depends on your level of tolerance to THC.
It may take some time and experimentation to find your sweet spot.
Your Body Doesn’t Process THC The Same Way
What about people who feel absolutely nothing, even after waiting for a long time or taking a relatively high dosage of edibles?
It is a unique phenomenon that not even scientists can fully explain yet.
What we do know is that all bodies metabolize all chemicals differently, and THC is no exception.
With that said, here are some of the reasons that may be causing you a hard time getting high from edibles.
- Lack of liver enzymes
- No gallbladder
- Surgery, gastric bypass
Lack of Liver Enzymes
When THC is digested, it is processed by the liver into a metabolite known as 11-OH-THC. It is this compound, not the THC, that causes the high.
Enzymes are responsible for converting THC into 11-OH-THC. Therefore, if there is a lack of these enzymes, the conversion does not happen, nor does the high experience.
Physiological differences or changes in the body may cause a decrease in these liver enzymes.
According to a study in the International Journal of Legal Medicine, how your body metabolizes THC and which enzymes it produces can vary greatly depending on your genes.
Poor metabolizers of THC had the presence of a CYP2C9 gene variant.
This means that for some individuals, not reacting to edibles may be genetic, and there may not be anything that can be done to change that.
Gallbladder
Many people claim a lack of gallbladder is to blame, but this is purely anecdotal.
For every person who has told me they have no gallbladder and don’t feel the effects of edibles, I’ve had another tell me they have no gallbladder and do feel the effects of edibles.
However, if you had your gallbladder removed, the effects of edibles can be either delayed or have a more rapid onset.
The gallbladder breaks down fats and makes them usable/absorbable, so fat-based preparations like butter and oils may not be processed by your body effectively.
Alcohol-based tinctures like the Green dragon or Golden dragon may be a better choice to try.
Your Tolerance Has Increased
You may wonder why you used to feel the effects of edibles, but now they don’t work for you.
This is because physiological changes associated with continuous use can change how you experience the high.
Over time, your body’s tolerance to THC and other cannabinoids increases. This means you simply need to take a larger dose to feel the same effect.
To counteract this, you may need to take a tolerance break.
Tips & Tricks To Try
So, are there any solutions to being “ediblocked”?
Well, yes. Here are a few options to try:
- Try digestive enzymes
- Try consuming with a meal or fat
- Try consuming with mango
- Move onto alternative methods
Digestive Enzymes
Supplementing with digestive enzymes may help to offset the lack of liver enzymes produced in the body.
Anecdotal reports suggest that trying enzymes with your edibles can help you feel the high faster and make it last longer.
Digestive enzymes are available OTC at your local store or online, but be sure to check with your doctor before trying something new.
Consume with a Meal or Fat
Some people find that taking edibles on an empty stomach produces little to no effect while taking edibles with a meal produces a much better result.
Cannabinoids are lipophilic, meaning they are attracted to fat. When paired with fat, the bioavailability is increased, meaning your body can use it more effectively.
And when you eat a meal, your digestive system works the way it should, producing enzymes to break down the food. This can help initiate the enzyme breakdown needed to convert THC into 11-OH-THC.
Pair With Mango
Anecdotally, consuming mangoes with edibles can help some people significantly. Mangoes have a terpene called myrcene that can enhance your cannabis experience.
The psychoactive element in THC is said to react with the terpenes from the mango, as part of the Entourage Effect, to enhance your high.
You can eat edibles alongside fresh mangoes, or you can make edibles that use mangoes as an active ingredient. Check out my mango edible recipes here.
Try Alternative Methods
If, after careful patience and experimentation, you find that edibles do not work for you, it may be time to move on to different consumption methods.
Edibles are just one of the five main cannabis application methods commonly used. Next, you can try:
- Sublingual – when placed under the tongue cannabis can be absorbed into the bloodstream
- Inhalation – it doesn’t have to be smoking; you can try vaping or dry herb vaping
- Topical – apply your favorite cannabis products directly to the skin for localized relief
- Suppository – when placed inside the body, cannabis can be absorbed into the bloodstream
Final Thoughts
Edibles can be great, but they are not always great for everyone.
I hope this guide gives you some clarity as to why this may be happening, as well as some new tips and tricks to try to enhance your experience!
Take your edibles to the next level…
My Edibles Made Easy Online Cooking Course will teach you how to easily make cannabis edibles and topical recipes at home. This step-by-step video course will teach you how to infuse, extract, and create edibles with many different product types – all from the comfort of your own home.
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I’ve smoked weed and hash for 45 years and I get plenty high when smoking (although I do have some tolerance) but everytime I have tried brownies or store bought edibles I barely feel a thing. The last time I tried a big dose of really strong store-bought edible that was stoning everyone who tried it but not me. And it really sucks because I have lung issues and someday edibles may be the only way I can consume THC and here they do not work for me…. 🙁
It sounds like you’re experiencing what’s known as “edible resistance”. There are a few reasons why edibles might not be working for you, but don’t give up hope yet. Some people have a slower or less efficient digestive process when it comes to converting THC into 11-hydroxy-THC, the form that produces the strong effects associated with edibles. Here are a few tips that might help:
Try eating a meal with fat before taking edibles: THC is fat-soluble, so consuming a fatty meal beforehand can help increase absorption.
Experiment with sublingual products: If digestion is the issue, try tinctures or lozenges that dissolve under your tongue. They bypass the digestive system and may work better for you.
Make your own edibles: If store-bought products don’t work, making your own with a longer decarboxylation process might make a difference. Decarbing fully ensures the THC is activated properly.
Start with smaller doses over time: Sometimes taking smaller doses consistently over a period of days can help your body “wake up” to the effects of edibles.
Consider other cannabinoids: Edibles with a combination of THC and CBD might offer a more noticeable effect for some people.
I hope some of these tips help! It might take a bit of trial and error, but finding the right method for you is definitely possible. Wishing you the best of luck! 😊
I really enjoy your reads and have learned a lot
Thank you so much for your kind words, Lisa! We’re thrilled that you enjoy the content and find it valuable. Your feedback motivates us to keep sharing more!
I’ve heard the milk thistle supplement may be able to “spark” the liver enzyme production as well….milk thistle is one of the many “liver aids” you’ll find over the counter….there’s actually quite a few supplements if you go looking online….but I honestly prefer my local walk-in pharmacy area and buy local.
it may have some “bearing” considering my primary care has had recommended them for going on 3 years now. and I will say I have NEVER had an issue with edibles, RSO, or tinctures. lol. the smallest dose will send me to the moon.
Hi Adam. Thank you for sharing your positive experience with milk thistle supplements and how they’ve benefited you!!
What is the name of a digestive enzyme? No edibles work for me. Im on methadone for pain and wonder if that has anything to do with why no effects.
But I also remember when I was a teen I smoked 2 joints the very 1st time and nothing happened. Yet all my friends were crazy ass high.
When my ex was growing hydroponically years ago his would light my would up. Most amazing weed I ever had in my life. Kept me alert with crazy energy and no pain. Very euphoric. I would love to be able to know and find that again 15years later. Cant ask him as he was murdered point blank back of head.
Any info would be appreciated, ty kindly ❤
Hi Bonnie. Thank you for sharing your experience and concerns with us. It’s understandable to seek effective pain relief, especially given your unique circumstances. Methadone can definitely affect how your body processes other substances, including THC in edibles.
One key factor could be the enzyme CPY2C9, which metabolizes THC in the liver. Variations in this enzyme might influence your body’s response to edibles. A digestive enzyme supplement like Now Super Enzymes might assist in better absorption and digestion of edibles. You can find it on Amazon: https://amzn.to/3yCSFAq. However, it’s crucial to consult with a healthcare provider before starting any new supplement regimen.
Everyone’s body is unique, and what works well for one person may not work the same for another. We appreciate your openness and are here to support you on your journey to finding relief and well-being.
Wishing you the best of luck, and please feel free to reach out with any more questions.
Hi Emily!!!
So I have just come across your article here actually a couple of your articles. I keep jumping from one to another but wow, it’s been an eye-opener. I’ve been going at this edible thing for about 6 months and I have had very little effect. I do not get high at all, I feel a little different but definitely not high at all .. I have eaten a whole 1000mg gummie bag from dispensary in one day from 9am-9pm and feel nothing!!! Tried every brand every kind,vape, drops . So AnyWho… I’m gastric bypass 20 yrs post. I have my gallbladder out and I’ve had liver issues. I don’t know if my liver failure(in the past) affects this or not, But either way, I guess I’m just gonna try to make my own thanks to your wonderful articles and all your amazing knowledge but before I do that, I’d like to try something from your amazing products to see if maybe it is a quality issue? Maybe I need a real good quality product? I am like to try everything before tempting my own.. before I spend hundreds of dollars to make my own, I’d like to try yours…. What would u recommend from your high-quality products for somebody like me?
Hi Tracy! Thank you so much for your kind words! It sounds like you’ve been on quite a journey with edibles. Given your medical history, especially with gastric bypass surgery, liver issues, and the removal of your gallbladder, it’s most likely these factors that are affecting how your body processes edibles.
Since you’ve tried various edibles with little to no effect, it might be worth exploring alternative methods that bypass the digestive system altogether. One highly recommended method is using a sublingual oil. When cannabis is absorbed under the tongue, it enters the bloodstream directly, providing a quicker and potentially more effective response compared to traditional edibles. Our Easy Cannabis-Infused MCT Oil is a popular choice for sublingual use and can be a great starting point.
Additionally, inhalation methods such as vaping or dry herb vaping can also offer rapid relief and may work better for you. Topicals and suppositories are other alternatives that provide localized or systemic effects without involving your digestive system.
I’d love for you to try our high-quality products before you decide to make your own and if sublingual oils sound appealing, you can start with our easy-to-use MCT oil. It’s designed for efficient absorption and could be exactly what you need.
Feel free to reach out if you have any more questions or need further guidance. Your health and comfort are our top priorities, and we’re here to support you every step of the way.
Really enjoyed this bit of info,..very informative,..thank you
We are so happy you found this helpful, Cindy! We appreciate your feedback!
Hello Emily!
I have been using cannabis for about 40+ years and I utilize cannabis concentrates for inhalation exclusively, by virtue of significantly higher tolerance than average folks. I wanted to transition to edibles or tinctures, as I’m seeking alternatives to inhalation; however nothing works and I get no effects at all and I mean nothing, including powerful edibles in all forms, capsules, tinctures, and it’s frustrating. I read that using a digestive enzyme might work, because I may not possess the digestive enzyme in my liver and I need this CPY2C9 enzyme as apparently it’s been said that “a gene known as CPY2C9 is behind the enzyme that helps metabolize THC”……….please advise about this and a potential product to try and how long before taking edibles, do I take the digestive enzymes (I saw some available on Amazon)?………Much thanks for your help and advisement- I’ll be very Grateful……….
Hi Joseph. Thank you for reaching out and sharing your experience. It’s possible that variations in the CPY2C9 enzyme, which metabolizes THC in the liver, might affect how your body responds to edibles. Trying a digestive enzyme supplement could be an option. These are typically taken just before or with a meal. However, it’s important to remember that everyone’s body is unique and may react differently to supplements. It’s highly recommended to consult with a healthcare provider before starting any new supplement regimen. We appreciate your curiosity and openness to trying new solutions, and we’re here to support you on this journey. Good luck!
Hi Emily,
You mention gastric bypass as a possible reason edibles won’t work for some people but you never explain that reason in any detail. I believe I’m in that position. I notice that when I drink alcohol I feel the effects very quickly but they also go away very quickly. With edibles I only feel slightly weird, not high. Do you have any advice?
Hi Wendy. In gastric bypass procedures, a large part of the stomach is bypassed, and the size of the remaining stomach is significantly reduced, which changes how food and other substances are digested and absorbed in your body. When it comes to edibles, the active ingredients, such as THC, are usually absorbed in the intestines, but because gastric bypass surgery alters the digestive system, the absorption process is affected, which usually leads to weaker or delayed effects.
If you’re finding that edibles aren’t working well for you, it could be worth exploring sublinguals, which are absorbed through the mouth rather than the digestive system. Easy Cannabis-Infused MCT Oil is our most popular sublingual guide and recipe! I hope this helps, but please don’t hesitate to reach back out if you have more questions. 😁
Hi Emily,
I would like to know if I can use my decarbed,
ground cannabis mixed in chocolate bars or cookies or is it better to
use cannabis butter instead?
Kathy
Hi Kathy. Yes, you can use decarbed, ground cannabis mixed in chocolate bars or cookies. However, it is important to note that using decarbed cannabis directly in baked goods can sometimes result in a grainy texture. If you want to avoid this, using cannabutter would be best.