Are you feeling frustrated with your lack of reaction to cannabis edibles? Or are you just looking for more education on how edibles work? Explore the many different reasons why edibles don’t work for everyone and get my tips and tricks for things to try and enhance your experience.

Why You Will Love This Guide

Many people rave about how edibles make them feel – euphoric, happy, relaxed.

Not only could they help to relieve pain and other unwanted symptoms, but THC edibles also can produce an intense high.

Unfortunately, several people feel frustrated and left out because they have never felt that high sensation from an edible before.

Just recently, a member from my Well With Cannabis Community recently asked: “Why don’t edibles get me high?”

My answer? There could be multiple different reasons!

And you’re going to have to do some detective work to find out what is going on with you.

In this guide, we will explore a few reasons why edibles may not be working for you and some different techniques you can try to see if you can change the way your body responds.

A picture of a stack of cannabis gummies.

Why Edibles Don’t Work For Everyone

Before getting started – if you’re brand new – I want you to first read my beginner’s guide to edibles.

I also want you to know that your tolerance for smoking, vaping, or inhaling has no influence on your tolerance for edibles.

With that being said, a lot of people enjoy edibles over smoking for so many reasons; the most common reason is health-related.

Another reason is the experience. The high from THC in edibles can be stronger and offer a different, whole-body experience.

With edibles, you can also enjoy a sustained high. The intoxicating effects have been known to last for at least four hours or more.

Additionally, edibles are pretty convenient as they are easy to consume and they’re discreet, especially around others.

Unfortunately, not everyone has the same experience with edibles.

There are some people who report not feeling any effect at all.

If this is you, there are some reasons why this may be happening.

  1. You didn’t decarb first
  2. You didn’t consume enough
  3. Your body doesn’t process THC the same way
  4. Your tolerance has increased

We will explore them more in-depth below.

A picture of an oven-safe baking dish with decarboxylated cannabis inside.

You Didn’t Decarb First

If you have never made edibles before, it may come as a surprise to hear that you need to decarb your cannabis first.

This process is needed to convert the cannabinoid THCA into its active form of THC.

Decarbing is a straightforward process that can easily be done by baking your cannabis in an oven or Instant Pot.

If you skip this process, you will be unlikely to feel the desired intoxicating effects of your edibles.

Remember, flower buds, trim, kief, and many concentrates all need to be decarbed before incorporating them into a recipe.

You Didn’t Consume Enough

A friend of mine once said that she felt absolutely nothing after consuming edibles, even after trying several times.

As it turns out, she just needed a higher dose for it to kick in.

Just like how fast edibles kick in is different for everyone, the amount you need to feel the effect can also differ.

While some people get high with as little as 2mg of THC, others do so at 30mg, while others won’t feel the effect until the dosing is past 100mg or more.

All that depends on your level of tolerance to THC.

It may take some time and experimentation to find your sweet spot.

Your Body Doesn’t Process THC The Same Way

What about people who feel absolutely nothing, even after waiting for a long time or taking a relatively high dosage of edibles?

It is a unique phenomenon that not even scientists can fully explain yet.

What we do know is that all bodies metabolize all chemicals differently, and THC is no exception.

With that said, here are some of the reasons that may be causing you a hard time getting high from edibles.

  1. Lack of liver enzymes
  2. No gallbladder
  3. Surgery, gastric bypass

Lack of Liver Enzymes

When THC is digested, it is processed by the liver into a metabolite known as 11-OH-THC. It is this compound, not the THC, that causes the high.

Enzymes are responsible for converting THC into 11-OH-THC. Therefore, if there is a lack of these enzymes, the conversion does not happen, nor does the high experience.

Physiological differences or changes in the body may cause a decrease in these liver enzymes.

According to a study in the International Journal of Legal Medicine, how your body metabolizes THC and which enzymes it produces can vary greatly depending on your genes.

Poor metabolizers of THC had the presence of a CYP2C9 gene variant.

This means that for some individuals, not reacting to edibles may be genetic, and there may not be anything that can be done to change that.


Many people claim a lack of gallbladder is to blame, but this is purely anecdotal.

For every person who has told me they have no gallbladder and don’t feel the effects of edibles, I’ve had another tell me they have no gallbladder and do feel the effects of edibles.

However, if you had your gallbladder removed, the effects of edibles can be either delayed or have a more rapid onset.

The gallbladder breaks down fats and makes them usable/absorbable, so fat-based preparations like butter and oils may not be processed by your body effectively.

Alcohol-based tinctures like the Green dragon or Golden dragon may be a better choice to try.

Your Tolerance Has Increased

You may wonder why you used to feel the effects of edibles, but now they don’t work for you.

This is because physiological changes associated with continuous use can change how you experience the high.

Over time, your body’s tolerance to THC and other cannabinoids increases. This means you simply need to take a larger dose to feel the same effect.

To counteract this, you may need to take a tolerance break.

Tips & Tricks To Try

So, are there any solutions to being “ediblocked”?

Well, yes. Here are a few options to try:

  1. Try digestive enzymes
  2. Try consuming with a meal or fat
  3. Try consuming with mango
  4. Move onto alternative methods

Digestive Enzymes

Supplementing with digestive enzymes may help to offset the lack of liver enzymes produced in the body.

Anecdotal reports suggest that trying enzymes with your edibles can help you feel the high faster and make it last longer.

Digestive enzymes are available OTC at your local store or online, but be sure to check with your doctor before trying something new.

Consume with a Meal or Fat

Some people find that taking edibles on an empty stomach produces little to no effect while taking edibles with a meal produces a much better result.

Cannabinoids are lipophilic, meaning they are attracted to fat. When paired with fat, the bioavailability is increased, meaning your body can use it more effectively.

And when you eat a meal, your digestive system works the way it should, producing enzymes to break down the food. This can help initiate the enzyme breakdown needed to convert THC into 11-OH-THC.

Pair With Mango

Anecdotally, consuming mangoes with edibles can help some people significantly. Mangoes have a terpene called myrcene that can enhance your cannabis experience.

The psychoactive element in THC is said to react with the terpenes from the mango, as part of the Entourage Effect, to enhance your high.

You can eat edibles alongside fresh mangoes, or you can make edibles that use mangoes as an active ingredient. Check out my mango edible recipes here.

Try Alternative Methods

If, after careful patience and experimentation, you find that edibles do not work for you, it may be time to move on to different consumption methods.

Edibles are just one of the five main cannabis application methods commonly used. Next, you can try:

  • Sublingual – when placed under the tongue cannabis can be absorbed into the bloodstream
  • Inhalation – it doesn’t have to be smoking; you can try vaping or dry herb vaping
  • Topical – apply your favorite cannabis products directly to the skin for localized relief
  • Suppository – when placed inside the body, cannabis can be absorbed into the bloodstream

Final Thoughts

Edibles can be great, but they are not always great for everyone.

I hope this guide gives you some clarity as to why this may be happening, as well as some new tips and tricks to try to enhance your experience!

About Emily

Hi, I’m Emily Kyle and I teach people just like you how to use cannabis to find joy, enhance productivity, improve relationships, and naturally support your overall health and wellness.

Leave a comment

Your email address will not be published. Required fields are marked *


  1. What is the name of a digestive enzyme? No edibles work for me. Im on methadone for pain and wonder if that has anything to do with why no effects.

    But I also remember when I was a teen I smoked 2 joints the very 1st time and nothing happened. Yet all my friends were crazy ass high.

    When my ex was growing hydroponically years ago his would light my would up. Most amazing weed I ever had in my life. Kept me alert with crazy energy and no pain. Very euphoric. I would love to be able to know and find that again 15years later. Cant ask him as he was murdered point blank back of head.

    Any info would be appreciated, ty kindly ❤

  2. Hi Bonnie. Thank you for sharing your experience and concerns with us. It’s understandable to seek effective pain relief, especially given your unique circumstances. Methadone can definitely affect how your body processes other substances, including THC in edibles.

    One key factor could be the enzyme CPY2C9, which metabolizes THC in the liver. Variations in this enzyme might influence your body’s response to edibles. A digestive enzyme supplement like Now Super Enzymes might assist in better absorption and digestion of edibles. You can find it on Amazon: However, it’s crucial to consult with a healthcare provider before starting any new supplement regimen.

    Everyone’s body is unique, and what works well for one person may not work the same for another. We appreciate your openness and are here to support you on your journey to finding relief and well-being.

    Wishing you the best of luck, and please feel free to reach out with any more questions.

  3. I’ve heard the milk thistle supplement may be able to “spark” the liver enzyme production as well….milk thistle is one of the many “liver aids” you’ll find over the counter….there’s actually quite a few supplements if you go looking online….but I honestly prefer my local walk-in pharmacy area and buy local.

    it may have some “bearing” considering my primary care has had recommended them for going on 3 years now. and I will say I have NEVER had an issue with edibles, RSO, or tinctures. lol. the smallest dose will send me to the moon.

  4. Hi Adam. Thank you for sharing your positive experience with milk thistle supplements and how they’ve benefited you!!